The processing of spatial data is a key component in the evaluation of hydrogen infrastructures. The transition from a fossil-fuel-based to a climate-neutral, hydrogen-based economy presents a wide range of challenges for all stakeholders. By utilizing geographic information systems (GIS) and our HYSCOPE simulation toolbox, we can map, analyze, and optimize – from a geo-technical and economic perspective – both the necessary conversion and new construction of infrastructure as well as the entire value chain of regional supply chains.