The “System Analysis” project, part of the “TransHyDE” flagship hydrogen project funded by the Federal Ministry of Education and Research (BMBF), addressed key questions regarding the future hydrogen infrastructure: Where, when, and how will hydrogen and its derivatives be produced, used, stored, and transported to ensure they reach the right application at the right time and under cost-effective conditions? Within the consortium, the Fraunhofer Institute for Solar Energy Systems ISE was responsible for the techno-economic modeling of potential regional hydrogen ecosystems, for which the model HYSCOPE was developed, as well as for sustainability assessments of the technology options considered in the project.